The effects of Modafinil are similar to those of traditional stimulants such as methylphenidate (Ritalin) and dextroamphetamine (Dexedrine), but modafinil has a novel physiological mechanism different from other stimulants. After more than two decades of research, scientists are still trying to figure out just how it manipulates the brain.
The chemical name for modafinil is 2-[(diphenylmethyl)sulfinyl]acetamide. The molecular formula is C15H15NO2S. H3 antagonists are promising clinical candidates for the treatment of excessive day time sleepiness and/or cognitive disorders.
The R enantiomer of modafinil, called armodafinil, is sold under the name Nuvigil.
| New: FDA approves Nuvigil |
Before taking Modafinil, talk to your doctor about any medical conditions you may have, including if you:
While Modafinil is FDA-approved for narcolepsy, OSAHS and SWSD, many physicians are prescribing it for patients who do not suffer from one of these conditions but exhibit similar symptoms. It is estimated that most of the Modafinil use in the United States is "off-label".
Modafinil is being prescribed to millions of people for "off-label" or “lifestyle” uses, including:
Currently, many clinical trials are taking place to assess the effectiveness in using Modafinil to treat other conditions than EDS associated with narcolepsy, OSAHS and SWSD.