Distribution: Vd: 0.9 L/kg
Protein binding: 60%, primarily to albumin
Metabolism: Hepatic; multiple pathways including CYP3A4
Half-life elimination: Effective half-life: 15 hours; Steady-state: 2-4 days
Time to peak, serum: 2-4 hours
Excretion: Urine (as metabolites, <10% as unchanged drug)

What are H3 receptors and antagonists?

Immunoreactivity studies show H3 antagonists activate neuronal cells in restricted rat brain regions in contrast to widespread activation after previous termmodafinilnext term or amphetamine treatment.

Can I take Modafinil if I’m on hormonal birth controls?

Yes, but Modafinil can affect hormonal birth control methods (contraceptives). Women who use hormonal contraceptives such as birth control pills, shots, implants, intrauterine devices (IUDs), or patches may have a higher chance of getting pregnant while taking Modafinil and for one month after discontinuing the use of Modafinil. Women should talk to their doctor about which birth control methods to use while taking Modafinil.

Can I take Modafinil if I’m pregnant or nursing?

Modafinil is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to a fetus. There are no adequate studies that assess effects of Modafinil in pregnant women or nursing mothers. If you are pregnant, planning to get pregnant, or are currently breast-feeding, you should talk to your doctor before taking Modafinil. Related, modafinil may reduce the effectiveness of some forms of birth control.

Can I take Modafinil if I’m a professional athlete?

The World Anti-Doping Agency (WADA) has included modafinil on its List of Prohibited Substances and Methods. Olympic athletes as well as professional athletes participating in other sporting events around the world may be disciplined if they test positive for modafinil.

Are there side effects?

See page on side effects.

Will taking Modafinil affect my ability to fall asleep at night or interrupt my sleep?

Modafinil has a 15-hour half life (the amount of time before half of the drug’s peak plasma levels are eliminated by the body), meaning that if you take a single dosage of the drug in the morning the drug will have little or no effect on your night-time sleep.

Do they prescribe Modafinil to kids?

Modafinil has not been approved by the Food and Drug Administration for pediatric use.

Can I become addicted to Modafinil?

Modafinil is a Schedule IV controlled substance. This means that Modafinil may be a target for people who abuse medicines or street drugs. However, certain chemical properties of modafinil, the active ingredient in Modafinil, reduce its potential for abuse. Because the drug is insoluble in water, it cannot be readily injected. Also, it degrades with heating, which severally hampers its effectiveness if smoked.

It is advised to keep your Modafinil in a safe place. Giving your prescription of Modafinil to anyone is against the law.

It was thought that modafinil had a low additive potential, especially compared to other stimulants. A recent study has cast doubt on that view and found that modafinil affects the same dopamine system in the brain that other drugs affect. So it may be physically addictive. In any case, use the drug only if you need it and are under a doctor's care.